Author

Todd G. Cook

Indiana University Indianapolis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Amanda Jo Fisher· 3 shared Angelia D. LockettiD· 3 shared Marta Teixeira Gomes· 3 shared Roberto F. MachadoiD· 3 shared Adrian L. OblakiD· 2 shared Christopher D Lloyd· 2 shared Micheala A. AldrediD· 2 shared P. De La CruziD· 2 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersPhysiology

Amanda Jo Fisher

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pulmonary Hypertension Promotes Neuroinflammation and Neurodegeneration

P. De La Cruz, Angelia D. Lockett, Marta Teixeira Gomes, Somanshu Banerjee, Asif Razee, Amanda Jo Fisher, Todd G. Cook, Christopher D Lloyd, Shino Magaki, Soban Umar, Adrian L. Oblak, Roberto F. Machado

This study shows that pulmonary hypertension increases microglia and astrocyte density, reduces neuronal density, and causes TDP-43 mislocalization in both rat and human brain tissue.

bioRxiv · Sep 2, 2025 · PreprintPhysiology

The mitochondrial unfolded protein response and metabolic reprogramming promote PASMC proliferation in response to sphingosine kinase-1/sphingosine-1-phosphate signaling

Angelia D. Lockett, Aaron Snow, Pontian Adogamhe, Justin R. Sysol, Manas Yadav, Tendo Mubuuke, Marta Teixeira Gomes, Todd G. Cook, Amanda Jo Fisher, Micheala A. Aldred, Roberto F. Machado

This study shows that the Sphk1/S1P/S1P2 signaling axis promotes PASMC proliferation in PAH via activation of the mitochondrial unfolded protein response (UPRmt), which can be inhibited to reduce vascular remodeling.

bioRxiv · Jun 10, 2025 · PreprintCell Biology

Loss of Tbx4 Affects Postnatal Lung Development and Predisposes to Pulmonary Hypertension.

Gabriel Maldonado-Velez, Elizabeth A. Mickler, Todd G. Cook, Micheala A. Aldred

This study shows that loss of Tbx4 in embryonic lung mesenchyme leads to postnatal lung developmental defects and increased pulmonary hypertension.

American Journal of Respiratory Cell and Molecular Biology · Mar 19, 2025Peer-reviewedGenetics

Partial Wwox Loss of Function Increases Severity of Murine Sepsis and Neuroinflammation

P. De La Cruz, Marta Teixeira Gomes, Angelia D. Lockett, Amanda Jo Fisher, Todd G. Cook, Patricia Smith, Christopher D Lloyd, Homer L. Twigg, Adrian L. Oblak, C. Marcelo Aldaz, Roberto F. Machado

The paper shows partial Wwox loss of function in mice worsens sepsis severity and neuroinflammation.

bioRxiv · Jan 17, 2025 · PreprintNeuroscience