NeuroscienceNeuro-OncologyPeer-reviewed
TREM2 mediates MHCII-associated CD4+ T cell response against gliomas
Jiaying Zheng, Lingxiao Wang, Shunyi Zhao…·Long‐Jun Wu
The paper shows that higher TREM2 expression in gliomas correlates with poor prognosis, but TREM2 deficiency does not improve outcomes in pre-clinical models, as it impairs myeloid cell phagocytosis and MHCII-dependent CD4+ T cell responses.
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