Aaron J. Johnson

The paper identifies a commensal-specific CD8αβ+ T cell population in the intestine driven by a single commensal species and shows how epithelial signals regulate their differentiation and restraint.

This study shows that virus-specific CD8 T cells are generated and reactivated in the bone marrow after brain viral infections, leading to changes in the bone marrow niche.

This study identifies age-associated delays in immune resolution to respiratory viral infection by analyzing single-cell RNA sequencing and flow cytometry data from young and aged mice.

This study shows that reducing Hv1 proton channels in macrophages improves antigen presentation and anti-tumor responses in glioma by altering macrophage behavior and immune response.

The paper identifies UDP-P2Y6 signaling as a key driver of microglial calcium activity, phagocytosis, and neuroinflammation during epileptogenesis.

The paper shows that higher TREM2 expression in gliomas correlates with poor prognosis, but TREM2 deficiency does not improve outcomes in pre-clinical models, as it impairs myeloid cell phagocytosis and MHCII-dependent CD4+ T cell responses.