Young Il Lee

This study generates a rat model of Duchenne muscular dystrophy using CRISPR/Cas9 and evaluates its functional and structural muscle pathologies across different ages.

This paper investigates dual S100A1 and ARC gene therapy for DMD cardiomyopathy, showing improved cardiac function and survival in mouse models and safety in canine models.

This study shows that disrupting DR5 disulfide bonds activates pro-apoptotic signaling and reveals DR5 disulfide bonding as a sensor and effector of ER stress in cancer cells.