Valentyn Kyrychenko

The paper investigates ophthalmologic phenotypes in a zebrafish model of severe Holoprosencephaly (HPE), finding anophthalmia as the strongest phenotype and a spectrum including cyclopia and synophthalmia.

This study uses CRISPR/Cas9 to generate zebrafish models of holoprosencephaly (HPE) by disrupting bmp7b and bmpr1ba, showing HPE and cyclopia phenotypes.

The paper investigates the role of BMP antagonists in early eye and forebrain development, finding that BMP ligand overexpression leads to HPE with anophthalmia instead of cyclopia.