Stephan Heermann

The paper investigates ophthalmologic phenotypes in a zebrafish model of severe Holoprosencephaly (HPE), finding anophthalmia as the strongest phenotype and a spectrum including cyclopia and synophthalmia.

This study uses CRISPR/Cas9 to generate zebrafish models of holoprosencephaly (HPE) by disrupting bmp7b and bmpr1ba, showing HPE and cyclopia phenotypes.

This study identifies BMP7 as a key growth factor promoting cardiomyocyte proliferation in both mouse and zebrafish models, with potential therapeutic applications for heart regeneration.

The paper investigates the role of BMP antagonists in early eye and forebrain development, finding that BMP ligand overexpression leads to HPE with anophthalmia instead of cyclopia.

This study shows that BMP signaling disrupts optic chiasm formation and retinal ganglion cell (RGC) pathfinding in zebrafish by affecting midline guidance cues and optic stalk morphogenesis.

This study identifies TGF{beta} as essential for optic fissure fusion, with BMP antagonists preventing excessive BMP signaling to facilitate closure.

This study investigates optic fissure closure in zebrafish using 4D time-lapse analysis, revealing a mechanism involving tissue flow, pioneer cells, and EMT-like processes leading to epithelial fusion.

The paper shows that epithelial flow into the optic cup, suppressed by BMP, drives eye morphogenesis by expanding the basal surface area of the optic cup.

This study identifies TGFb signaling's role in optic fissure closure through ECM remodeling, regulated by BMP antagonists in zebrafish and supported by TGFb KO mouse coloboma phenotype.