The paper investigates ophthalmologic phenotypes in a zebrafish model of severe Holoprosencephaly (HPE), finding anophthalmia as the strongest phenotype and a spectrum including cyclopia and synophthalmia.

DOI 10.1002/cne.70113

zebrafishexperimental assay

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Developmental BiologyAnimal Cells and SystemsPeer-reviewedJul 1, 2025

Holoprosencephaly and Cyclopia in bmp7b and bmpr1ba Crispant zebrafish

Valentyn Kyrychenko, Philipp Rensinghoff, Johannes Bulk…·Stephan Heermann

This study uses CRISPR/Cas9 to generate zebrafish models of holoprosencephaly (HPE) by disrupting bmp7b and bmpr1ba, showing HPE and cyclopia phenotypes.

1 citation

zebrafishexperimental assay

𝕏 PostBluesky

Developmental BiologybioRxivPreprintDec 1, 2022

Early eye and forebrain development are facilitated by Bone Morphogenetic Protein antagonism

Johannes Bulk, Valentyn Kyrychenko, Philipp Rensinghoff, Stephan Heermann

The paper investigates the role of BMP antagonists in early eye and forebrain development, finding that BMP ligand overexpression leads to HPE with anophthalmia instead of cyclopia.

DOI 10.1101/2022.12.01.518698

mouseexperimental assay

𝕏 PostBluesky