Lucia Rossi

This study identifies NAD+ limitation and α-ketoglutarate depletion as mechanisms by which pancreatic cancer cells induce muscle atrophy through metabolic rewiring and redox imbalance.

This paper develops a human iPSC-based model of L-CMD to test gene editing strategies for muscle laminopathies, showing partial reversal of disease phenotypes with precise mutation correction.

The paper develops a 3D in vitro model of graft-host skeletal muscle interaction using decellularized skeletal muscle constructs and neuromuscular organoids, showing functional neuromuscular junction formation and regeneration.