Author

Yona Tugg

Michael G. DeGroote Institute for Infectious Disease ResearchORCID 0009-0000-2107-6344Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Art MarzokiD· 2 shared Jann Catherine Ang· 2 shared Jonathan Mapletoft· 2 shared Matthew S. MilleriD· 2 shared Sam AfkhamiiD· 2 shared Vithushan SurendraniD· 2 shared Ali ZhangiD· 1 shared Andrew CheniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersImmunology

Art MarzokORCID

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2 papers

Recent·Most cited

ImmunologyNature CommunicationsPeer-reviewedAug 29, 2026

Acute Viral Infection Accelerates Neurodegeneration in a Mouse Model of ALS

Art Marzok, Jonathan Mapletoft, Imran Ahmed…·Matthew S. Miller

Acute viral infection accelerates ALS progression in SOD1G93A mice by inducing gliosis and metabolic dysregulation, which can be mitigated by anti-inflammatory or antiviral treatments.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintSep 23, 2025

Senataxin is required for optimal class switch recombination to the immunoglobulin A isotype

Vithushan Surendran, Jonathan Mapletoft, Peter YF. Zeng…·Matthew S. Miller

This study shows that senataxin deficiency impairs class switch recombination to IgA in vitro, reduces IgA response to infection, and decreases IgA repertoire diversity in vivo.

DOI 10.1101/2025.09.23.678005

mousebulk RNA-seq

𝕏 PostBluesky