Author

Jonathan Mapletoft

Michael G. DeGroote Institute for Infectious Disease Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Art MarzokiD· 2 shared Jann Catherine Ang· 2 shared Matthew S. MilleriD· 2 shared Sam AfkhamiiD· 2 shared Vithushan SurendraniD· 2 shared Yona TuggiD· 2 shared Ali ZhangiD· 1 shared Andrew CheniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersImmunology

Art MarzokORCID

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2 papers

Recent·Most cited

Acute Viral Infection Accelerates Neurodegeneration in a Mouse Model of ALS

Art Marzok, Jonathan Mapletoft, Imran Ahmed, Braeden Cowbrough, Daniel B. Celeste, Michael R. D’Agostino, Jann Catherine Ang, Andrew Chen, Vithushan Surendran, Yona Tugg, Hahn Li, Karena Wong, Anna Dvorkin‐Gheva, Ali Zhang, Hannah D. Stacey, , Matthew S. Miller

Acute viral infection accelerates ALS progression in SOD1G93A mice by inducing gliosis and metabolic dysregulation, which can be mitigated by anti-inflammatory or antiviral treatments.

Nature Communications · Aug 29, 2026Peer-reviewedImmunology

Senataxin is required for optimal class switch recombination to the immunoglobulin A isotype

Vithushan Surendran, Jonathan Mapletoft, Peter YF. Zeng, Julia Avolio, Sam Afkhami, Joshua J.C. McGrath, Andrew T. Chen, Art Marzok, Jann Catherine Ang, Kyle Amaral, Yona Tugg, Martin R. Stämpfli, Matthew S. Miller

This study shows that senataxin deficiency impairs class switch recombination to IgA in vitro, reduces IgA response to infection, and decreases IgA repertoire diversity in vivo.

bioRxiv · Sep 23, 2025 · PreprintImmunology