Minal B. Patel

The paper fine-maps GWAS risk variants for PDAC and identifies candidate target genes through chromatin conformation capture, finding functional interactions and eQTLs at specific loci.

This study identifies rs9581943 as a causal variant in a PDAC GWAS signal, showing it reduces PDX1 expression and impairs stress buffering in exocrine pancreatic cells.

The paper identifies functional variants and VNTRs at the 5p15.33 locus using fine-mapping, MPRA, and CRISPRi screens, revealing their role in cancer susceptibility through antagonistic pleiotropy.

The paper identifies a spatiotemporal cancer cell trajectory in glioblastoma that explains tumor heterogeneity across regions and subclones.

The paper identifies non-coding mutations in enhancer clusters associated with pancreatic ductal adenocarcinoma and validates their functional impact using computational and experimental methods.