Jun Wang

The paper identifies a 6-gene stromal signature, Stroma6, that predicts early relapse in low-risk and chemoresistant breast cancer patients, independent of Oncotype DX results.

This study shows that Lamin B1 protects B cell genomes by preventing DNA damage and regulating chromatin accessibility, with its loss linked to poor lymphoma outcomes.

The paper assembles haploid genomes of Muscovy ducks and analyzes genetic, expression, and regulatory patterns of parental alleles in the ZW system, finding differences in chromatin accessibility and gene expression between maternal and paternal haplotypes.

This study shows LIMD1 is essential for effective miRNA targeting and repression by AGO2, revealing its role in expanding miRNA regulatory capacity beyond conserved targets.

This study identifies PTPN11/SHP2-driven adenosine signaling as a mechanism of immune escape in JMML, showing that CD39 inhibition can enhance T cell responses and reduce myeloproliferation.

This study identifies DEK::NUP214 as an XPO1-dependent transcriptional activator of leukemia genes, showing selective response to XPO1 inhibitors in t(6;9) AML cases.

The paper identifies non-coding mutations in enhancer clusters associated with pancreatic ductal adenocarcinoma and validates their functional impact using computational and experimental methods.

IBRAP is a tool that benchmarks scRNA-seq analysis pipelines by allowing interchangeable methods and metrics to find optimal combinations for different data types and studies.

The paper identifies DNA copy number alterations and chromosome-scale losses caused by replication stress in non-transformed cells, revealing their role in chromosomal instability and cancer evolution.

IW-Scoring integrates 11 algorithms to annotate and prioritize noncoding genetic variations, outperforming individual methods and identifying recurrently mutated regions in follicular lymphoma.