Azait Imtiaz

The paper reconstructs the evolution of a human-specific endogenous retrovirus, K111, showing its role in shaping structural diversity at acrocentric nucleolar organizer regions through parental transmission and remodeling.

The paper shows that centromeric α-satellite DNA is prone to genotoxic damage, incomplete repair, and cytoplasmic mislocalization, leading to chromosome instability and chromatin antigen exposure.

This study identifies HELLS as a regulator of SSB repair and DNA alkylation damage response, showing its synthetic lethality with HRD in cancer.

This study shows bleomycin causes centromere damage and chromatin mislocalization in fibroblasts, linking it to systemic sclerosis features.