Wioletta Czaja

The paper shows that centromeric α-satellite DNA is prone to genotoxic damage, incomplete repair, and cytoplasmic mislocalization, leading to chromosome instability and chromatin antigen exposure.

This study identifies HELLS as a regulator of SSB repair and DNA alkylation damage response, showing its synthetic lethality with HRD in cancer.

This study shows bleomycin causes centromere damage and chromatin mislocalization in fibroblasts, linking it to systemic sclerosis features.

This study shows that primary cilia in cholangiocytes regulate DNA damage response and repair, with deciliated cells showing increased DNA damage and reduced survival under genotoxic stress.

This study shows that Fyn-mediated phosphorylation of Menin disrupts telomere maintenance in stem cells by altering Menin's interaction with telomerase components.

The paper introduces a cell-based assay called alk-BER to measure DNA alkylation damage and repair rates, offering a reliable and reproducible method for studying BER activity in various cell types.