Bo-Ruei Chen

Centromeric α-satellite DNA is a hotspot of genotoxic damage, incomplete repair, and cytoplasmic mislocalization

The paper shows that centromeric α-satellite DNA is prone to genotoxic damage, incomplete repair, and cytoplasmic mislocalization, leading to chromosome instability and chromatin antigen exposure.

Chromatin regulator HELLS mediates SSB repair and responses to DNA alkylation damage.

This study identifies HELLS as a regulator of SSB repair and DNA alkylation damage response, showing its synthetic lethality with HRD in cancer.

Bleomycin induces active-centromere damage and cytoplasmic mislocalization of centromeric chromatin in fibroblasts

This study shows bleomycin causes centromere damage and chromatin mislocalization in fibroblasts, linking it to systemic sclerosis features.