Double mutation of open syntaxin and UNC-18 P334A leads to excitatory-inhibitory imbalance and impairs multiple aspects of C. elegans behavior
Mengjia Huang, Ya Wang, Chun Hin Chow, Karolina P. Stepien, Karen Indrawinata, Junjie Xu, Peter Argiropoulos, Xiaoyu Xie, Kyoko Sugita, Chi-Wei Tien, Soomin Lee, Philippe Patrick Monnier, Josep Rizo, Shangbang Gao, Shuzo Sugita
The paper investigates the combined effects of two exocytosis-enhancing mutations in C. elegans and finds they disrupt excitatory-inhibitory balance and impair multiple behaviors.
bioRxiv · Aug 18, 2023 · PreprintNeuroscience