Author

Karolina P. Stepien

The University of Texas Southwestern Medical CenterORCID 0000-0003-0373-8919Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 2 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:C. elegans· 2 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Josep RizoiD· 3 shared Kyoko Sugita· 2 shared Mengjia HuangiD· 2 shared Philippe Patrick MonnieriD· 2 shared Shangbang GaoiD· 2 shared Shuzo SugitaiD· 2 shared Xiaoyu XieiD· 2 shared A. JoachimiakiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Josep RizoORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 9, 2026

Cryo-EM structure of detergent-bound Vibrio cholerae MakA captures a candidate intermediate between the soluble form and mature assembly of an α-pore-forming toxin

Yirui Guo, Bradley Quade, Karolina P. Stepien…·Zbyszek Otwinowski

The paper reports a cryo-EM structure of detergent-bound Vibrio cholerae MakA, revealing its conformational changes and role in pore assembly.

DOI 10.64898/2026.09.08.748681

bacteria (other)cryo-EM

𝕏 PostBluesky

NeurosciencebioRxivPreprintAug 18, 2023

Double mutation of open syntaxin and UNC-18 P334A leads to excitatory-inhibitory imbalance and impairs multiple aspects of C. elegans behavior

Mengjia Huang, Ya Wang, Chun Hin Chow…·Shuzo Sugita

The paper investigates the combined effects of two exocytosis-enhancing mutations in C. elegans and finds they disrupt excitatory-inhibitory balance and impair multiple behaviors.

DOI 10.1101/2023.08.18.553709

C. elegansexperimental assay

𝕏 PostBluesky

NeuroscienceNature CommunicationsPeer-reviewedNov 2, 2020

Open syntaxin overcomes synaptic transmission defects in diverse C. elegans exocytosis mutants

Chi-Wei Tien, Bin Yu, Mengjia Huang…·Shuzo Sugita

This study shows that overexpressing an open form of syntaxin can rescue exocytosis defects in multiple C. elegans mutants, suggesting a general mechanism to enhance synaptic transmission.

22 citations

C. elegansexperimental assay

𝕏 PostBluesky