Josep Rizo

The paper reports a cryo-EM structure of detergent-bound Vibrio cholerae MakA, revealing its conformational changes and role in pore assembly.

This study shows that tau aggregation can be reduced by modifying sequences near the PGGG β-turn motif, while maintaining microtubule binding, offering therapeutic insights for neurodegenerative diseases.

This paper identifies two VHH antibodies that selectively bind pathogenic tau seeds in AD and related tauopathies, showing potential for therapeutic and diagnostic applications.

This paper proposes a lever hypothesis for Synaptotagmin-1 action in neurotransmitter release, suggesting it pulls SNARE complexes to facilitate membrane fusion.

This study identifies two distinct regions in the synaptotagmin-1/SNARE complex interface that mediate different functions in neurotransmitter release and shows that Ca2+ triggers a rearrangement of this interface.

This study investigates how the N-terminal region of Munc13-1 inhibits its activity and how this inhibition is relieved by RIMs and calmodulin.

The paper investigates the combined effects of two exocytosis-enhancing mutations in C. elegans and finds they disrupt excitatory-inhibitory balance and impair multiple behaviors.

This study investigates how mutations in the C1C2B region of Munc13-1 affect neurotransmitter release and presynaptic plasticity in murine hippocampal cultures.

This study shows that overexpressing an open form of syntaxin can rescue exocytosis defects in multiple C. elegans mutants, suggesting a general mechanism to enhance synaptic transmission.