Author

Shuzo Sugita

University Health NetworkORCID 0000-0002-9182-873XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 4 Organism:C. elegans· 3 Research Focus:cell type annotation· 2 Assay:electronic health records· 2

Frequent Co-Authors

Mengjia HuangiD· 7 shared Chun Hin ChowiD· 6 shared Philippe Patrick MonnieriD· 6 shared Hidekiyo HaradaiD· 4 shared Hong‐Shuo SuniD· 3 shared Sarah EideiD· 3 shared Shangbang GaoiD· 3 shared Zhong‐Ping FengiD· 3 shared

Activity by Year

2020-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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7 shared papersNeuroscience

Mengjia HuangORCID

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7 papers

Recent·Most cited

Segregated localization of target-SNARE proteins within presynaptic terminals of Munc18-1 deficient photoreceptors

Mengjia Huang, Chun Hin Chow, Jason Charish, Karen Indrawinata, Hidekiyo Harada, Valerie A. Wallace, Philippe Patrick Monnier, Shuzo Sugita

The paper investigates the localization of SNARE proteins in Munc18-1 deficient photoreceptors and finds that Munc18-1 prevents segregation of syntaxin-3 and SNAP-25 in presynaptic terminals.

bioRxiv · Dec 19, 2024 · PreprintNeuroscience

SNAP-25, but not SNAP-23, is essential for photoreceptor function and survival in mice

Mengjia Huang, Chun Hin Chow, Akshay Gurdita, Hidekiyo Harada, Victor Q. B. Pham Truong, Sarah Eide, Hong‐Shuo Sun, Zhong‐Ping Feng, Philippe Patrick Monnier, Valerie A. Wallace, Shuzo Sugita

bioRxiv · Aug 25, 2023 · PreprintNeuroscience

Differential Regulation of Excitatory vs Inhibitory Synaptic Release by Complexin/CPX-1 and CAPS/UNC-31 at the C. elegans Neuromuscular Junctions

Ya Wang, Chun Hin Chow, Mengjia Huang, Randa Higazy, Neeraja Ramakrishnan, Cuntai Zhang, Shuzo Sugita, Shangbang Gao

This study investigates the roles of complexin/CPX-1 and CAPS/UNC-31 in regulating excitatory and inhibitory synaptic release at C. elegans neuromuscular junctions, revealing distinct regulatory patterns and interactions.

bioRxiv · Aug 25, 2023 · PreprintNeuroscience

Mouse model of multiple sclerosis induced by disrupting vesicular transport in oligodendrocytes

Chun Hin Chow, Mengjia Huang, Jayant Rai, Hidekiyo Harada, Sarah Eide, Hong‐Shuo Sun, Zhong‐Ping Feng, Philippe Patrick Monnier, Kenichi Okamoto, Liang Zhang, Shuzo Sugita

This study shows that disrupting vesicular transport in adult oligodendrocytes causes demyelination and neuroinflammation, contributing to Multiple Sclerosis.

bioRxiv · Aug 24, 2023 · PreprintNeuroscience

Double mutation of open syntaxin and UNC-18 P334A leads to excitatory-inhibitory imbalance and impairs multiple aspects of C. elegans behavior

Mengjia Huang, Ya Wang, Chun Hin Chow, Karolina P. Stepien, Karen Indrawinata, Junjie Xu, Peter Argiropoulos, Xiaoyu Xie, Kyoko Sugita, Chi-Wei Tien, Soomin Lee, Philippe Patrick Monnier, Josep Rizo, Shangbang Gao, Shuzo Sugita

The paper investigates the combined effects of two exocytosis-enhancing mutations in C. elegans and finds they disrupt excitatory-inhibitory balance and impair multiple behaviors.

bioRxiv · Aug 18, 2023 · PreprintNeuroscience

Neuronal SNAP-23 scales hippocampal synaptic plasticity and memory

Mengjia Huang, Na‐Ryum Bin, Jayant Rai, Ke Ma, Chun Hin Chow, Sarah Eide, Hidekiyo Harada, Jianbing Xiao, Daorong Feng, Hong‐Shuo Sun, Zhong‐Ping Feng, Herbert Y. Gaisano, Jeffrey E. Pessin, Philippe Patrick Monnier, Kenichi Okamoto, , Shuzo Sugita

This study shows that neuronal SNAP-23 is essential for hippocampal synaptic plasticity and spatial memory but not for basal glutamate receptor function.

iScience · Apr 13, 2023Peer-reviewedNeuroscience

Open syntaxin overcomes synaptic transmission defects in diverse C. elegans exocytosis mutants

Chi-Wei Tien, Bin Yu, Mengjia Huang, Karolina P. Stepien, Kyoko Sugita, Xiaoyu Xie, Liping Han, Philippe Patrick Monnier, Mei Zhen, Josep Rizo, Shangbang Gao, Shuzo Sugita

This study shows that overexpressing an open form of syntaxin can rescue exocytosis defects in multiple C. elegans mutants, suggesting a general mechanism to enhance synaptic transmission.

Nature Communications · Nov 2, 2020Peer-reviewedNeuroscience