Akshara Dubey

This study shows that SOX2 maintains regulatory continuity between cochlear epithelium and spiral ganglion neurons by sustaining enhancer activity and neurotrophic gene expression.

The paper traces the evolutionary history of transcription factor repertoires in prokaryotes, finding early diversification and steady innovation contrasting with eukaryotic bursts.

The paper examines the evolutionary dynamics of transcription factor and non-transcription factor DNA-binding superfamilies across eukaryotic clades, revealing differences in their scaling and evolutionary rates.

The paper uses laboratory evolution experiments to show that E. coli initiates constitutive stable DNA replication (cSDR) predominantly in a region ~0.6 Mb clockwise of oriC, and that genome inversions help resolve replication-transcription conflicts.