Raj K. Ladher

This study shows that SOX2 maintains regulatory continuity between cochlear epithelium and spiral ganglion neurons by sustaining enhancer activity and neurotrophic gene expression.

This study identifies a non-canonical Notch-Wnt interaction that maintains prosensory domain identity by regulating Sox2 and Lmx1a through NICD-mediated suppression of Wnt activity.

The paper identifies cell-shape dynamics as a mechanism for generating organisational diversity in sensory epithelia across species.

The paper shows that the timing of inner ear neuron delamination determines their topography and target innervation in the developing eighth cranial nerve.

The paper identifies a transient population of cells during chick otic vesicle closure that mediate epithelial fusion through a partial epithelial-mesenchymal transition.

The paper investigates the role of Pcdh15-CD2 in establishing intrinsic polarity of inner ear hair cells, showing its necessity for kinocilial migration and polarity restoration.

This study shows that mitochondrial dysfunction in a novel mouse model impairs early lineage specification and embryonic development, highlighting mitochondrial roles in developmental transitions.

The paper shows that patterned junctional contractility coordinates cell behavior in mixed epithelia, leading to spatial order and 3D tissue structure during development.

The paper investigates how compartment coupling coordinates patterning and morphogenetic information in the mouse organ of Corti, revealing vinculin-dependent junctional mechanics as a key mechanism.

The paper investigates stereocilia formation in mouse cochlear hair cells using microscopy and actin analysis, revealing early actin dynamics and structural changes during development.

The paper shows that Shh's morphogenic and mitogenic roles are segregated on distinct exosomal pools regulated by Rab7 levels during spinal cord development.