Author
Broad InstituteORCID 0009-0000-8750-8138Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Shervin Tabrizi, Claire Sullivan, Kasturi Chakraborty…·John Christopher Love
This paper identifies molecular features of monoclonal antibodies that enhance ctDNA detection by increasing its concentration in blood.
Ruolin Liu, Eugenia Roberts, Heather Anne Parsons…·Viktor A. Adalsteinsson
DirectHRD is a whole-genome sequencing-based classifier that improves HRD detection sensitivity in low tumor fraction samples.
Shervin Tabrizi, Carmen Martin-Alonso, Kan Xiong…·John Christopher Love
A DNA-binding agent increases cfDNA levels in blood, improving ctDNA detection and cancer sensitivity in mice.
Carmen Martin-Alonso, Shervin Tabrizi, Kan Xiong…·Sangeeta N. Bhatia
A nanoparticle priming agent increases cfDNA levels in blood, improving ctDNA detection sensitivity in tumor-bearing mice.
Kan Xiong, Douglas Shea, Justin Rhoades…·Viktor A. Adalsteinsson
The paper identifies DNA strand resynthesis as a source of false mutations in sequencing and introduces Duplex-Repair to reduce this error, improving sequencing accuracy.
Gregory Gydush, Erica Nguyen, Jin H. Bae…·Viktor A. Adalsteinsson
MAESTRO enables efficient and accurate tracking of thousands of low-frequency mutations with reduced sequencing, improving mutation testing in cancer and liquid biopsies.