Author
Harvard–MIT Division of Health Sciences and TechnologyORCID 0000-0001-6581-7909Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Cathy S. Wang, Qian Zhong, Shih‐Ting Wang…·Sangeeta N. Bhatia
The paper identifies caspase-1 as a target for lung cancer interception by analyzing protease activity in a murine model and showing reduced tumor formation with combined IL-1b and caspase-1 inhibition.
Shervin Tabrizi, Claire Sullivan, Kasturi Chakraborty…·John Christopher Love
This paper identifies molecular features of monoclonal antibodies that enhance ctDNA detection by increasing its concentration in blood.
Carmen Martin-Alonso, Sarah Alamdari, Tahoura S. Samad…·Ava Amini
CleaveNet is an AI pipeline that designs protease substrates with high efficiency and selectivity, validated experimentally for MMP13.
Shervin Tabrizi, Carmen Martin-Alonso, Kan Xiong…·John Christopher Love
A DNA-binding agent increases cfDNA levels in blood, improving ctDNA detection and cancer sensitivity in mice.
Carmen Martin-Alonso, Shervin Tabrizi, Kan Xiong…·Sangeeta N. Bhatia
A nanoparticle priming agent increases cfDNA levels in blood, improving ctDNA detection sensitivity in tumor-bearing mice.
Ava P. Soleimany, Carmen Martin-Alonso, Melodi Anahtar…·Sangeeta N. Bhatia
The paper introduces PAA, a toolkit for analyzing protease activity data, offering preprocessing, visualization, and machine learning tools to standardize analysis across in vitro and in vivo assays.