Milton A. English

This study provides a comprehensive multiomic analysis of non-glaucomatous human trabecular meshwork cells using data from multiple laboratories.

The paper identifies 78 genes associated with elevated intraocular pressure and primary open-angle glaucoma by analyzing chromatin dynamics and integrating GWAS variants with 3D chromatin landscapes.

The paper shows that glycolysis and lactate regulate histone H3K18 lactylation to control gene expression in retinal development and maturation.

This study shows reserpine improves photoreceptor function and preservation in a rhodopsin P23H rat model of RP, with greater benefits observed in female rats.

The paper identifies interactions between NRL and RNA-binding proteins, including R-loops in retinal photoreceptors, revealing new roles for NRL in transcription and gene regulation.