Matthew Nemeth

ESM3, a 98-billion-parameter multimodal protein language model tokenized across sequence, structure, and function, designs a bright green fluorescent protein at 58% sequence identity to known fluorescent proteins.

This paper introduces RESPLICE, a CRISPR-based trans-splicing system that efficiently edits endogenous human transcripts, achieving up to 90% trans-splicing efficiency in sorted cells.

The paper systematically characterizes gene function in a photosynthetic organism by analyzing mutant phenotypes across diverse conditions and linking them to functional pathways.