Author

Ryan A. Goettl

University of KentuckyORCID 0009-0001-2416-4232Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1

Frequent Co-Authors

Avery R. ChildressiD· 2 shared Christian M. GosseriD· 2 shared Christine F. BrainsoniD· 2 shared Daniel R. PlaugheriD· 2 shared Dave-Preston I. Esoe· 2 shared Erika M. SkaggsiD· 2 shared Jinpeng LiuiD· 2 shared Kassandra J. NaughtoniD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Avery R. ChildressORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

EZH1/2 inhibition improves immunotherapy response through MHC Class II de-repression and neutrophil reprogramming

Avery R. Childress, Dave-Preston I. Esoe, Xiulong Song, Christian M. Gosser, Yindan Lin, Daniel R. Plaugher, Tanner J. DuCote, Kassandra J. Naughton, Erika M. Skaggs, Harrison Yang, Ryan A. Goettl, Jinpeng Liu, Zhonglin Hao, Albert Fliss, Daisuke Honma, , Christine F. Brainson

This study shows that EZH1/2 inhibition with valemetostat enhances anti-PD1 immunotherapy in lung squamous cell carcinoma by increasing MHC Class II and reprogramming neutrophils.

bioRxiv · Aug 1, 2026 · PreprintCancer Biology

Methionine Restriction Reduces Lung Cancer Progression and Increases Chemotherapy Response

Kassandra J. Naughton, Xiulong Song, Avery R. Childress, Erika M. Skaggs, Aria L. Byrd, Christian M. Gosser, Dave-Preston I. Esoe, Tanner J. DuCote, Daniel R. Plaugher, Alexsandr Lukyanchuk, Ryan A. Goettl, Jinpeng Liu, Christine F. Brainson

This study shows that methionine restriction reduces lung cancer progression and enhances chemotherapy response in a mouse model and human cell lines.

bioRxiv · Jun 25, 2024 · PreprintCancer Biology