Author

Alina Aaltonen

Karolinska InstitutetORCID 0009-0001-2893-3000Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Assay:electronic health records· 1 Assay:imaging· 1

Frequent Co-Authors

Anders BorgkvistiD· 4 shared Emanuela SantiniiD· 4 shared Ayu Tamaki· 2 shared Ori J. LiebermaniD· 2 shared Andrés Peris Ramón· 1 shared Avery F. McGuirtiD· 1 shared Chiara CriscuoloiD· 1 shared Clarissa Anna PisanòiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersNeuroscience

Anders BorgkvistORCID

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4 papers

Recent·Most cited

DARPP-32 in motor cortex regulates structural and synaptic plasticity in corticothalamic neurons and enables motor learning.

Clarissa Anna Pisanò, Alina Aaltonen, Valeria Spanu, Ayu Tamaki, Gilberto Fisone, Emanuela Santini, Anders Borgkvist

This study shows that DARPP-32 in motor cortex is essential for synaptic plasticity and motor learning by regulating dendritic spines and long-term potentiation in corticothalamic neurons.

bioRxiv · May 5, 2026 · PreprintNeuroscience

Altered striatal long-term potentiation in the eIF4E- TG ASD mouse model

Alina Aaltonen, Jone Razquin, Julia Oyrer, Chiara Criscuolo, Ori J. Lieberman, Eric Klann, Anders Borgkvist, Emanuela Santini

This study investigates how overexpression of the eIF4E gene in mice affects striatal long-term potentiation (LTP), finding increased LTP that is NMDA receptor-dependent but not blocked by D1/D2 receptor antagonists.

bioRxiv · Mar 6, 2026 · PreprintNeuroscience

Postnatal reduction of eIF4E overexpression in D1-SPNs ameliorates KCNQ dysfunction, hyperexcitability and ASD-like behaviours.

Alina Aaltonen, Ayu Tamaki, Andrés Peris Ramón, Anders Borgkvist, Emanuela Santini

This study shows that reducing eIF4E overexpression in D1-SPNs of adult mice improves KCNQ function, hyperexcitability, and ASD-like behaviors.

Cellular and Molecular Life Sciences · Feb 18, 2026Peer-reviewedNeuroscience

Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders.

Josep Carbonell-Roig, Alina Aaltonen, Karin Wilson, Maya Molinari, Veronica Cartocci, Avery F. McGuirt, Eugene V. Mosharov, Ján Kehr, Ori J. Lieberman, David L. Sulzer, Anders Borgkvist, Emanuela Santini

This study investigates dopamine neurotransmission in an eIF4E Tg mouse model of ASD, finding impaired striatal dopamine release and behavioral inflexibility due to defective nicotinic receptor signaling.

Cell Reports · Nov 27, 2024Peer-reviewedNeuroscience