Emanuela Santini

This study shows that DARPP-32 in motor cortex is essential for synaptic plasticity and motor learning by regulating dendritic spines and long-term potentiation in corticothalamic neurons.

This study investigates how overexpression of the eIF4E gene in mice affects striatal long-term potentiation (LTP), finding increased LTP that is NMDA receptor-dependent but not blocked by D1/D2 receptor antagonists.

This study shows that reducing eIF4E overexpression in D1-SPNs of adult mice improves KCNQ function, hyperexcitability, and ASD-like behaviors.

This study investigates dopamine neurotransmission in an eIF4E Tg mouse model of ASD, finding impaired striatal dopamine release and behavioral inflexibility due to defective nicotinic receptor signaling.

The paper investigates how dopamine modulates GABA release from striatonigral synapses via 5-HT1B receptors, revealing a serotonergic mechanism relevant to Parkinson's disease treatments.

This study shows that HNRNPU deficiency causes chromatin remodeling, transcriptional changes, and delayed neurogenesis in hindbrain-derived neural progenitors.

The paper investigates how cell-type-specific disruptions in cortico-striatal circuits in FXS model mice lead to repetitive behaviors and identifies potential therapeutic targets.

This study shows that reducing PERK-eIF2α signaling in dopaminergic neurons causes cognitive and age-related motor issues in mice.

The paper shows that mTOR suppresses autophagy in the striatum during postnatal development, with autophagic flux reaching adult levels by P28.

The paper shows that learning regulates protein synthesis in adult rat amygdala axons, identified through TRAP-RNASeq, revealing upregulated mitochondrial and translation-related genes and downregulated synaptic genes.