Cell BiologyThe EMBO JournalPeer-reviewed
NFAT2 drives both Orai3 transcription and protein degradation by harnessing the differences in epigenetic landscape of MARCH8 E3 ligase
Sharon Raju, Akshay Sharma, Sakshi Dahiya…·Rajender K. Motiani
This paper shows NFAT2 regulates Orai3 expression differently in non-metastatic and metastatic cancer cells through transcriptional activation and MARCH8-mediated degradation, linked to MARCH8 promoter methylation.
8 citations