Author

Beate Wittbrodt

Heidelberg UniversityORCID 0009-0001-3691-6227Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:zebrafish· 2 Assay:CRISPR screen· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Joachim WittbrodtiD· 2 shared Thomas ThumbergeriD· 2 shared Christian ThieliD· 1 shared E. SalvadoriD· 1 shared Erika TsingosiD· 1 shared Isabelle Thomas· 1 shared Johanna RaschiD· 1 shared José Arturo Gutierrez-Triana· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersDevelopmental Biology

Joachim WittbrodtORCID

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2 papers

Recent·Most cited

Developmental BiologyBiology OpenPeer-reviewedNov 7, 2025

Establishing an auxin-inducible GFP nanobody-based acute protein knockdown system to mimic hypomorphic mutations during early medaka embryogenesis

Kaisa Pakari, Sevinç Jakab, Johanna Rasch…·Thomas Thumberger

The paper establishes an auxin-inducible system to acutely knock down Pmm2 protein in medaka, mimicking hypomorphic mutations seen in PMM2-CDG patients.

2 citations

zebrafishexperimental assay

𝕏 PostBluesky

GeneticseLifePeer-reviewedAug 20, 2018

Efficient single-copy HDR by 5’ modified long dsDNA donors

José Arturo Gutierrez-Triana, Tinatini Tavhelidse, Thomas Thumberger…·Joachim Wittbrodt

The paper demonstrates that modifying the 5' ends of long dsDNA donors enhances HDR efficiency in Medaka, enabling efficient single-copy integration through monomeric donor conformation.

102 citations

zebrafishCRISPR screen

𝕏 PostBluesky