Epigenetic priming promotes acquisition of tyrosine kinase inhibitor resistance and oncogene amplification in human lung cancer
Rebecca M. Starble, Eric G. Sun, Rana Gbyli, Jonathan S. D. Radda, Jiuwei Lu, Tyler B Jensen, Ning Sun, Nelli Khudaverdyan, Bomiao Hu, Mary Ann Melnick, Shuai Zhao, Nitin Roper, Gang Greg Wang, Jikui Song, Katerina A. Politi, , Andrew Xiao
The paper identifies METTL7A as a factor that promotes TKI resistance and oncogene amplification in lung cancer by remodeling chromatin structure before copy number gains.
bioRxiv · Jan 26, 2025 · PreprintGenetics