This study reports the structure of the AMT complex bound to OCR protein, revealing its substrate binding mechanism and conformational changes during 6mA methylation.

Protein Science · Aug 15, 2025Peer-reviewedBiochemistry

Epigenetic priming promotes acquisition of tyrosine kinase inhibitor resistance and oncogene amplification in human lung cancer

Rebecca M. Starble, Eric G. Sun, Rana Gbyli, Jonathan S. D. Radda, Jiuwei Lu, Tyler B Jensen, Ning Sun, Nelli Khudaverdyan, Bomiao Hu, Mary Ann Melnick, Shuai Zhao, Nitin Roper, Gang Greg Wang, Jikui Song, Katerina A. Politi, , Andrew Xiao

The paper identifies METTL7A as a factor that promotes TKI resistance and oncogene amplification in lung cancer by remodeling chromatin structure before copy number gains.

bioRxiv · Jan 26, 2025 · PreprintGenetics

Semi-conservative transmission of DNA N6-adenine methylation in a unicellular eukaryote

Yalan Sheng, Yuanyuan Wang, Wentao Yang, Xue Qing David Wang, Jiuwei Lu, Bo Pan, Bei Nan, Yongqiang Liu, Fei Ye, Chun Li, Jikui Song, Yali Dou, Shan Gao, Yifan Liu

The paper demonstrates that DNA N6-adenine methylation (6mA) is transmitted semi-conservatively in Tetrahymena thermophila, with AMT1-dependent maintenance and AMT1-independent de novo methylation mechanisms.

Genome Research · May 1, 2024Peer-reviewedMolecular Biology

Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms

Linfeng Gao, Max Emperle, Yiran Guo, Sara A. Grimm, Wendan Ren, Sabrina Adam, Hidetaka Uryu, Zhimin Zhang, Dongliang Chen, Jiekai Yin, Michael Dukatz, Hiwot Anteneh, Renata Zofia Jurkowska, Jiuwei Lu, Yinsheng Wang, , Jikui Song

This study characterizes the structure-function differences between DNMT3A and DNMT3B, revealing distinct mechanisms of de novo DNA methylation and their implications in epigenomic alterations.

Nature Communications · Jul 3, 2020Peer-reviewedGenetics