Author

Jonathan S. D. Radda

Yale UniversityORCID 0000-0002-2242-9604Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

Siyuan S. WangiD· 4 shared Andrew XiaoiD· 2 shared Shengyan JiniD· 2 shared Tyler B JenseniD· 2 shared Yubao ChengiD· 2 shared Bing YangiD· 1 shared Bomiao HuiD· 1 shared Chongzhi ZangiD· 1 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersGenetics

Siyuan S. WangORCID

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4 papers

Recent·Most cited

Excessive immune responses in preterm placental villi compromise trophoblast health

Tyler Rice, Yi Cao, Leon Bichmann, Mar Ivar Ribes, Taylor Snisky, Serrena Singh, Weihong Gu, Dean Yimlamai, Jonathan S. D. Radda, Siyuan S. Wang, Raffaella Morotti, John S. Tsang, Christina Megli, Liza Konnikova

The paper examines immune cell composition and function in placental villi, finding that excessive T cells and cytokines in preterm cases impair trophoblast health.

bioRxiv · Sep 20, 2025 · PreprintImmunology

Non-disruptive 3D profiling of combinations of epigenetic marks in single cells

Yanbo Chen, Jonathan S. D. Radda, Myles H. Alderman, Shengyan Jin, Yubao Cheng, Yuan‐Ming Zhang, Miao Liu, Andrew Xiao, Siyuan S. Wang

This paper introduces Epi-PHR, a non-disruptive method for single-cell spatial epigenetic profiling, revealing region-specific epigenetic profiles and allele-specific chromatin states.

bioRxiv · Jun 13, 2025 · PreprintGenetics

Perturb-tracing enables high-content screening of multiscale 3D genome regulators

Yubao Cheng, Mengwei Hu, Bing Yang, Tyler B Jensen, Yuan Zhang, Tianqi Yang, Ruihuan Yu, Zhaoxia Ma, Jonathan S. D. Radda, Shengyan Jin, Chongzhi Zang, Siyuan S. Wang

The paper introduces Perturb-tracing, a high-content screening platform to identify regulators of 3D chromatin organization, discovering new factors that influence chromatin folding and nuclear architecture.

Nature Methods · Apr 10, 2025Peer-reviewedGenetics

Epigenetic priming promotes acquisition of tyrosine kinase inhibitor resistance and oncogene amplification in human lung cancer

Rebecca M. Starble, Eric G. Sun, Rana Gbyli, Jonathan S. D. Radda, Jiuwei Lu, Tyler B Jensen, Ning Sun, Nelli Khudaverdyan, Bomiao Hu, Mary Ann Melnick, Shuai Zhao, Nitin Roper, Gang Greg Wang, Jikui Song, Katerina A. Politi, , Andrew Xiao

The paper identifies METTL7A as a factor that promotes TKI resistance and oncogene amplification in lung cancer by remodeling chromatin structure before copy number gains.

bioRxiv · Jan 26, 2025 · PreprintGenetics