Cell BiologybioRxivPreprint
Species-Specific Roles of RIPK1 and TRADD in TNF-Induced Cell Death Reveal a Translational Gap Between Mouse Models and Human Biology
Zhao Deng, Buhao Deng, Jingyi Wang…·Bo Yan
This study identifies species-specific differences in TNF-induced cell death mechanisms between human and mouse cells, highlighting discrepancies in RIPK1 and TRADD function that affect drug efficacy.