Jiafan Yuan

Species-Specific Roles of RIPK1 and TRADD in TNF-Induced Cell Death Reveal a Translational Gap Between Mouse Models and Human Biology

This study identifies species-specific differences in TNF-induced cell death mechanisms between human and mouse cells, highlighting discrepancies in RIPK1 and TRADD function that affect drug efficacy.

mTORC1 Directs TNF-Induced Life-or-Death Decisions via Complex I Destabilization

This paper shows mTORC1 regulates TNF-induced cell death by destabilizing complex I and promoting complex II formation, with implications for disease therapies.