Kathryn C. Fitzgerald

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

The paper identifies multicellular molecular programs associated with RV adaptation in PAH using single-nucleus RNA sequencing and integrates them with physiological measurements.

The paper shows that indole lactate (ILA), reduced in MS, restores gut microbiome metabolic balance, promoting remyelination and reducing neuroinflammation.

This study shows bile acid metabolism is altered in multiple sclerosis, and supplementation with tauroursodeoxycholic acid reduces neuroinflammation in animal models.

The paper identifies low-frequency coding variants contributing to multiple sclerosis risk using a large case-control study.