BiochemistrybioRxivPreprint
BTK dynamics and function are differentially influenced by distinct covalent inhibitor warhead chemistries.
Raji E. Joseph, Robert G. Britton, David Yin-wei Lin…·Amy Hamilton Andreotti
This study compares the effects of different warhead chemistries in covalent inhibitors on BTK dynamics and function, showing that 2-butynamide induces conformational heterogeneity and reduced efficacy compared to acrylamide.
DOI 10.64898/2026.05.07.723540