Author

Jeffrey A. Purslow

Iowa State UniversityORCID 0000-0001-8828-0809Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Amy Hamilton AndreottiiD· 1 shared D. Bruce Fulton· 1 shared David Yin-wei LiniD· 1 shared Julien RocheiD· 1 shared M. Paul GleesoniD· 1 shared Martin J.S. DyeriD· 1 shared Poowadon FukasemiD· 1 shared Raji E. JosephiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Amy Hamilton AndreottiORCID

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1 paper

Recent·Most cited

BTK dynamics and function are differentially influenced by distinct covalent inhibitor warhead chemistries.

Raji E. Joseph, Robert G. Britton, David Yin-wei Lin, Julien Roche, Jeffrey A. Purslow, D. Bruce Fulton, Poowadon Fukasem, M. Paul Gleeson, Martin J.S. Dyer, Thomas E. Wales, Amy Hamilton Andreotti

This study compares the effects of different warhead chemistries in covalent inhibitors on BTK dynamics and function, showing that 2-butynamide induces conformational heterogeneity and reduced efficacy compared to acrylamide.

bioRxiv · Oct 17, 2026 · PreprintBiochemistry