Author

D. Bruce Fulton

Iowa State University

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Biochemistry· 1

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Amy Hamilton AndreottiiD· 1 shared David Yin-wei LiniD· 1 shared Jeffrey A. PurslowiD· 1 shared Julien RocheiD· 1 shared M. Paul GleesoniD· 1 shared Martin J.S. DyeriD· 1 shared Poowadon FukasemiD· 1 shared Raji E. JosephiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBiochemistry

Amy Hamilton AndreottiORCID

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1 paper

Recent·Most cited

BTK dynamics and function are differentially influenced by distinct covalent inhibitor warhead chemistries.

Raji E. Joseph, Robert G. Britton, David Yin-wei Lin, Julien Roche, Jeffrey A. Purslow, D. Bruce Fulton, Poowadon Fukasem, M. Paul Gleeson, Martin J.S. Dyer, Thomas E. Wales, Amy Hamilton Andreotti

This study compares the effects of different warhead chemistries in covalent inhibitors on BTK dynamics and function, showing that 2-butynamide induces conformational heterogeneity and reduced efficacy compared to acrylamide.

bioRxiv · Oct 17, 2026 · PreprintBiochemistry