Author

Martin J.S. Dyer

University of LeicesterORCID 0000-0002-5033-2236Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Amy Hamilton AndreottiiD· 1 shared Andrea G. S. PepperiD· 1 shared Chris J. PepperiD· 1 shared D. Bruce Fulton· 1 shared David Yin-wei LiniD· 1 shared Ielyaas CloeteiD· 1 shared Jeffrey A. PurslowiD· 1 shared Julien RocheiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Amy Hamilton AndreottiORCID

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2 papers

Recent·Most cited

BTK dynamics and function are differentially influenced by distinct covalent inhibitor warhead chemistries.

Raji E. Joseph, Robert G. Britton, David Yin-wei Lin, Julien Roche, Jeffrey A. Purslow, D. Bruce Fulton, Poowadon Fukasem, M. Paul Gleeson, Martin J.S. Dyer, Thomas E. Wales, Amy Hamilton Andreotti

This study compares the effects of different warhead chemistries in covalent inhibitors on BTK dynamics and function, showing that 2-butynamide induces conformational heterogeneity and reduced efficacy compared to acrylamide.

bioRxiv · Oct 17, 2026 · PreprintBiochemistry

Computational modeling of DLBCL predicts response to BH3-mimetics.

Ielyaas Cloete, Victoria M. Smith, Ross A. Jackson, Andrea G. S. Pepper, Chris J. Pepper, Meike Vogler, Martin J.S. Dyer, Simon A. Mitchell

This study uses computational systems biology to predict DLBCL cell response to BH3-mimetics by modeling molecular variability and genetic lesions.

npj Systems Biology and Applications · Jun 6, 2023Peer-reviewedSystems Biology