Author

Robert G. Britton

Iowa State UniversityORCID 0000-0001-8813-1635Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Amy Hamilton AndreottiiD· 2 shared D. Bruce Fulton· 2 shared Martin J.S. DyeriD· 2 shared Raji E. JosephiD· 2 shared Thomas E. WalesiD· 2 shared David Yin-wei LiniD· 1 shared Jeffrey A. PurslowiD· 1 shared John R. EngeniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

Amy Hamilton AndreottiORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 17, 2026

BTK dynamics and function are differentially influenced by distinct covalent inhibitor warhead chemistries.

Raji E. Joseph, Robert G. Britton, David Yin-wei Lin…·Amy Hamilton Andreotti

This study compares the effects of different warhead chemistries in covalent inhibitors on BTK dynamics and function, showing that 2-butynamide induces conformational heterogeneity and reduced efficacy compared to acrylamide.

DOI 10.64898/2026.05.07.723540

humanexperimental assay

𝕏 PostBluesky

BiochemistryeLifePeer-reviewedNov 19, 2024

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.

Raji E. Joseph, Thomas E. Wales, Sandrine Jayne…·Amy Hamilton Andreotti

This study examines how different BTK inhibitors affect BTK conformation and explains resistance mutation patterns in CLL patients.

3 citations

humanprotein structure

𝕏 PostBluesky