Erica Bresciani

The paper examines organ-specific microenvironmental MR1 expression in cutaneous melanoma using zebrafish models and imaging techniques, finding differential immune responses and metabolism in brain versus skeletal metastases.

The paper analyzes genomic data from patients with FPDMM to identify germline RUNX1 variants and somatic mutations linked to clonal hematopoiesis and myeloid malignancies.

This study shows that RUNX1 in granulocyte-monocyte progenitors limits neutrophil inflammatory cytokine production by restricting retrotransposon chromatin accessibility and type I interferon signaling.

The paper identifies RUNX1-independent mechanisms for hematopoietic stem cell generation and shows that GATA2 and RUNX1 functionally complement each other in hematopoiesis.