Paul Liu

A conserved vesicular circuit enables metabolic adaptation and maintains systemic heme homeostasis

The paper identifies a conserved vesicular circuit that maintains heme homeostasis by rerouting intracellular heme flux, showing its role in metabolic adaptation across species.

Genomic Landscape of Patients with Germline RUNX1 Variants and Familial Platelet Disorder with Myeloid Malignancies in a Natural History Study

The paper analyzes genomic data from patients with FPDMM to identify germline RUNX1 variants and somatic mutations linked to clonal hematopoiesis and myeloid malignancies.

Clonal hematopoiesis in individuals with ANKRD26 or ETV6 germline mutations

This study examines clonal hematopoiesis risk in individuals with germline ANKRD26 or ETV6 mutations, finding that ANKRD26 carriers have elevated risk while ETV6 carriers do not.

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

The paper identifies RUNX1-independent mechanisms for hematopoietic stem cell generation and shows that GATA2 and RUNX1 functionally complement each other in hematopoiesis.

RUNX1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells: Mechanistic studies and drug correction

This study shows that RUNX1 haploinsufficiency reduces megakaryocyte-biased hematopoietic progenitor cells and identifies drug targets to correct this defect.

A metabolic shift to glycolysis promotes zebrafish tail regeneration through TGF-β dependent dedifferentiation of notochord cells to form the blastema