Author

Hélène Bigonne

ETH ZurichORCID 0009-0001-6584-8884Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:metabolomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:rat· 1 Approach:simulation· 1

Frequent Co-Authors

Georg AichingeriD· 3 shared Shana J. SturlaiD· 3 shared Jacob S. FolziD· 2 shared Aishwarya MuraliiD· 1 shared Amrei Rolof· 1 shared Bennard van RavenzwaayiD· 1 shared Franziska Maria ZickgrafiD· 1 shared Hennicke KampiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

Georg AichingerORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintJul 30, 2026

Chemical probes reveal individualized gut microbiome biotransformation capacity and the impacts of ex vivo fermentation conditions

Jacob S. Folz, Raúl Fernández Cereijo, Maja Stevanoska…·Shana J. Sturla

This paper develops a fermentation workflow to assess gut microbiome biotransformation capacity using chemical probes and metabolomics, showing that experimental conditions and donor variability influence transformation profiles.

DOI 10.64898/2026.07.30.741225

humanmetabolomics

𝕏 PostBluesky

Pharmacology & ToxicologyEnvironmental Science & TechnologyPeer-reviewedSep 25, 2025

Human internal exposures of bisphenol A and six data-poor analogues predicted by physiologically based kinetic models with multimodal parameterization

Hélène Bigonne, Amrei Rolof, Inga Potapova…·Georg Aichinger

The paper predicts internal exposures of bisphenol analogs using physiologically based kinetic models with multimodal parameterization, showing variability in concentrations by age, sex, and organ.

12 citationstop 4%

humanstatistical model

𝕏 PostBluesky

MicrobiologybioRxivPreprintMay 20, 2025

Chemical activity profiling reveals how exposure to drugs or dietary compounds alters gut microbial biotransformation capacity

Hélène Bigonne, Shuhuan Zhai, Jacob S. Folz…·Shana J. Sturla

The paper profiles chemical activities in rat gut microbiota to assess changes in biotransformation capacity after exposure to drugs and dietary compounds, finding significant alterations with certain antibiotics.

DOI 10.1101/2025.05.20.655107

ratmetabolomics

𝕏 PostBluesky