Phosphorylation code of human nucleophosmin includes four cryptic sites for hierarchical binding of 14-3-3 proteins
Anna A. Kapitonova, Kristina V. Tugaeva, Richard B. Cooley, Nikolai N. Sluchanko
This study identifies four phosphorylation sites in NPM1 that enable 14-3-3 protein binding, revealing how phosphorylation regulates NPM1's nucleocytoplasmic shuttling and structural dynamics.