Author

Khoi Le

University of MinnesotaORCID 0009-0002-0824-0730Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Khoi Le1 paper · Brown University

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Anja‐Katrin BielinskyiD· 2 shared Aaron Nathan SneadiD· 1 shared Arshia Zernab HassaniD· 1 shared Aulma R. ParkeriD· 1 shared Benjamin D. HorningiD· 1 shared Brent M. KuenziiD· 1 shared Chad L. MyersiD· 1 shared Charles M. BooneiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Anja‐Katrin BielinskyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Suppression of NRF2-dependent cancer growth by a covalent allosteric molecular glue

Nilotpal Roy, Tine L Wyseure, I‐Chung Lo, Justine Lu, Christie L. Eissler, Steffen M. Bernard, Ilah Bok, Aaron Nathan Snead, Aulma R. Parker, U‐Ging Lo, Jason C. Green, Jordon M. Inloes, Sarah R. Jacinto, Brent M. Kuenzi, Marie Pariollaud, , Matthew P. Patricelli

This paper introduces VVD-065, a covalent NRF2 inhibitor that enhances NRF2 degradation and sensitizes tumors to therapy, supporting a Phase I clinical trial.

Cancer Discovery · Dec 19, 2025Peer-reviewedCancer Biology

Cell type specific suppression of hyper-recombination by human RAD18 is linked to PCNA K164 ubiquitination

Colette B. Rogers, Wendy Leung, Ryan M. Baxley, Rachel E. Kram, Liangjun Wang, Joseph P. Buytendorp, Khoi Le, David A. Largaespada, Eric A. Hendrickson, Anja‐Katrin Bielinsky

The paper shows that RAD18 inactivation in HCT116 cells increases recombination and reduces TLS activity, linked to PCNA K164 ubiquitination, but not SUMOylation.

bioRxiv · Sep 3, 2024 · PreprintMolecular Biology

A scalable platform for efficient CRISPR-Cas9 chemical-genetic screens of DNA damage-inducing compounds

Kevin C. Lin, Ya‐Chu Chang, Maximilian Billmann, Henry N. Ward, Khoi Le, Arshia Zernab Hassan, Urvi Bhojoo, Katherine Chan, Michael Costanzo, Jason Moffat, Charles M. Boone, Anja‐Katrin Bielinsky, Chad L. Myers

The paper presents a scalable CRISPR-Cas9 platform for chemical-genetic screens of DNA damage-inducing compounds, identifying enriched modes-of-action and revealing late ICL repair pathway responses.

Scientific Reports · Jan 30, 2024Peer-reviewedSystems Biology