Author

Kevin C. Lin

University of MinnesotaORCID 0000-0003-2067-059XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Arshia Zernab HassaniD· 2 shared Chad L. MyersiD· 2 shared Charles M. BooneiD· 2 shared Henry N. WardiD· 2 shared Jason MoffatiD· 2 shared Katherine ChaniD· 2 shared Maximilian BillmanniD· 2 shared Michael CostanzoiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSystems Biology

Arshia Zernab HassanORCID

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2 papers

Recent·Most cited

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

Maximilian Billmann, Michael Costanzo, Xiang Zhang, Arshia Zernab Hassan, Mahfuzur Rahman, Kevin R. Brown, Katherine Chan, Amy H.Y. Tong, Carles Pons, Henry N. Ward, Catherine Ross, Jolanda S. van Leeuwen, Michael Aregger, Keith A. Lawson, Barbara Mair, , Charles M. Boone

The paper constructs a genome-scale genetic interaction network from 4 million double mutants in HAP1 cells, revealing conserved genetic network principles across species and uncovering novel gene functions and cancer dependencies.

bioRxiv · Jun 30, 2025 · PreprintSystems Biology

A scalable platform for efficient CRISPR-Cas9 chemical-genetic screens of DNA damage-inducing compounds

Kevin C. Lin, Ya‐Chu Chang, Maximilian Billmann, Henry N. Ward, Khoi Le, Arshia Zernab Hassan, Urvi Bhojoo, Katherine Chan, Michael Costanzo, Jason Moffat, Charles M. Boone, Anja‐Katrin Bielinsky, Chad L. Myers

The paper presents a scalable CRISPR-Cas9 platform for chemical-genetic screens of DNA damage-inducing compounds, identifying enriched modes-of-action and revealing late ICL repair pathway responses.

Scientific Reports · Jan 30, 2024Peer-reviewedSystems Biology