Zachary S. Greenspan

Beyond Fixation: Persistent Genetic Variation Under Intense Selection

This study shows that genetic variation persists under intense directional selection in Drosophila and can be rapidly redeployed when selection reverses, suggesting balancing-selection maintains this variation.

The Microbiotas Response to Host Adaptive Evolution

The paper examines microbiota changes in Drosophila melanogaster populations selected for different aging trajectories, finding a consistent loss of Wolbachia in short-lived populations and its dominance in long-lived ones.

Selection for early reproduction leads to accelerated aging and extensive metabolic remodeling in Drosophila melanogaster

This study uses metabolomic profiling in Drosophila melanogaster to show that selection for early reproduction leads to repeatable metabolic changes and a reliable predictor of biological age.

The genetic basis of Drosophila melanogaster defense against Beauveria bassiana explored through evolve and resequence and quantitative trait locus mapping

This study investigates the genetic basis of Drosophila melanogaster's defense against Beauveria bassiana using QTL mapping and evolve and resequence approaches, revealing genetic variation and trade-offs in immune defense.