Author

Anastasia Pupo

Northeastern UniversityORCID 0009-0004-3511-0776Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:Drosophila· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Kenneth Ryan ArnoldiD· 2 shared M. A. PhillipsiD· 2 shared Ryan Daniel RobinsoniD· 2 shared Valeria Vanessa ChavariniD· 2 shared Zachary S. GreenspaniD· 2 shared Antentor Othrell Hinton Jr.iD· 1 shared Benjamin R. HarrisoniD· 1 shared Corrina O. CannelliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersEvolutionary Biology

Kenneth Ryan ArnoldORCID

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2 papers

Recent·Most cited

Beyond Fixation: Persistent Genetic Variation Under Intense Selection

Kenneth Ryan Arnold, Zachary S. Greenspan, Ryan D. Robinson, Anastasia Pupo, Valeria Vanessa Chavarin, Kevin S. Chang, Corrina O. Cannell, Miao Qi, Laurence D. Mueller, Michael R. Rose, Mark Phillips

This study shows that genetic variation persists under intense directional selection in Drosophila and can be rapidly redeployed when selection reverses, suggesting balancing-selection maintains this variation.

Molecular Biology and Evolution · Jul 24, 2026Peer-reviewedEvolutionary Biology

Selection for early reproduction leads to accelerated aging and extensive metabolic remodeling in Drosophila melanogaster

David L. Hubert, Kenneth Ryan Arnold, Zachary S. Greenspan, Anastasia Pupo, Ryan Daniel Robinson, Valeria Vanessa Chavarin, Thomas T. Barter, Danijel Djukovic, Daniel Raftery, Zer Vue, Antentor Othrell Hinton Jr., Melanie R. McReynolds, Benjamin R. Harrison, M. A. Phillips

This study uses metabolomic profiling in Drosophila melanogaster to show that selection for early reproduction leads to repeatable metabolic changes and a reliable predictor of biological age.

Genome Biology and Evolution · Apr 30, 2025Peer-reviewedEvolutionary Biology