MicrobiologybioRxivPreprint
Optineurin Deficiency Collapses the Host Endolysosomal Network and Impairs Xenophagy to Accelerate Mycobacterium tuberculosis Growth
Nalin Abeydeera, Jeffrey Chin, Angel Ruvalcaba…·Jonathan M. Budzik
This study shows Optineurin deficiency disrupts the endolysosomal network and impairs xenophagy, leading to increased Mycobacterium tuberculosis growth and necrotic cell death.
DOI 10.64898/2026.08.23.746595